Measles-induced encephalitis.

ارزیابی تستهای CF و HI در تشخیص بعضی از عفونتهای ویروسی سیستم مغزی-نخاعی قسمت اول: آنسفالیت سرخکی (Measles Encephalitis)

Recombinant Measles AIK-C Vaccine Strain Expressing the prM-E Antigen of Japanese Encephalitis Virus

An inactivated Japanese encephalitis virus (JEV) vaccine, which induces neutralizing antibodies, has been used for many years in Japan. In the present study, the JEV prM-E protein gene was cloned, inserted at the P/M junction of measles AIK-C cDNA, and an infectious virus was recovered. The JEV E protein was expressed in B95a cells infected with the recombinant virus. Cotton rats were inoculate...

Intracerebral inoculation of rhesus monkeys with a strain of measles virus isolated from a case of subacute sclerosing panencephalitis.

Measles virus isolated from the brain of a patient with subacute sclerosing panencephalitis was injected intracerebrally (ic) into 34 rhesus monkeys. Groups of these animals were injected with measles antigen in Freund's complete adjuvant or treated by schedules used for suppression of the general or cell-mediated immune responsiveness. In another group of animals, experimental allergic encepha...

Inhibition of major histocompatibility complex class II-dependent antigen presentation by neutralization of gamma interferon leads to breakdown of resistance against measles virus-induced encephalitis.

BALB/c mice are resistant to measles virus (MV)-induced encephalitis due to their strong MV-specific CD4(+) T-cell response. Resistance is broken by neutralization of gamma interferon with monoclonal antibodies, indicating an important role for this pleiotropic cytokine. Here, we demonstrate that mouse gamma interferon has no direct antiviral effect in vitro and in vivo. The breakdown of resist...

Measles virus in the CNS: the role of viral and host factors for the establishment and maintenance of a persistent infection.

Acute measles (for review see: Grif®n and Bellini, 1996) can be accompanied by early or late central nervous system (CNS) complications. These include the acute postinfectious measles encephalitis (APME), which develops 2 ± 4 weeks after infection, or as late complications, the measles inclusion body encephalitis (MIBE) in immunocompromised patients, and the subacute sclerosing panencephalitis ...